Blog Post Author Biography: Alan Needle is a Professor at Appalachian State University in the Department of Public Health and Exercise Science and the Department of Rehabilitation Sciences. He has been a certified and licensed athletic trainer since 2007, and conducts research related to assessing and treating neurological impairments in individuals with ankle sprains and chronic ankle instability.
Citation: Gottlieb U, Hayek R, Hoffman JR, Springer S. Exercise combined with electrical stimulation for the treatment of chronic ankle instability – A randomized controlled trial. J Electromyogr Kines. 2024; 74: 102856. https://doi.org/10.1016/j.jelekin.2023.102856.
Take-to-the-clinic message: Combining neuromuscular electrical stimulation with balance exercises improved long-term ankle function in individuals with chronic ankle instability better than therapeutic exercise combined with transcutaneous electrical nerve stimulation. These effects were observed with 12 total treatment sessions over 4-6 weeks, with improvements seen at 6 and 12 months following the intervention.
Background: While therapeutic exercises are a common method for treating individuals with chronic ankle instability (CAI), continued high rates of re-injury and many required treatment sessions creates a need for manners to augment CAI rehabilitation. In individuals with ACL injury, forms of electrical stimulation, including transcutaneous electrical nerve stimulation (TENS) and neuromuscular electrical stimulation (NMES) are often implemented to address neurological changes following injury. TENS and NMES have shown limited efficacy in individuals with CAI; however, it is unclear how they would affect function when combined with therapeutic exercise.
Purpose: This study aimed to assess the short, medium, and long-term effects of balance training in conjunction with NMES or TENS on dynamic postural control and patient-reported outcome measures.
Methods: This study implemented a double-blind randomized controlled trial design conducted in 34 young adults with CAI, following International Ankle Consortium guidelines. Participants were randomized into groups receiving NMES or TENS over the peroneal (fibularis) muscles, while all individuals conducted ankle rehabilitation exercises emphasizing static and dynamic balance. Outcome measures included dynamic balance conducted through a Y-balance test and time-to-stabilization from a single-leg drop jump. Patient function was quantified through the Foot and Ankle Ability Measure (FAAM) activities of daily living (FAAM-ADL) and sport subscales (FAAM-Sport), as well as the Cumberland Ankle Instability Tool (CAIT) and Identification of Functional Ankle Instability (IdFAI) instrument. Participants were instructed on performing the balance exercises and operation of a portable electrical stimulation device, with exercises being conducted during active stimulation. Participants performed 12 total treatment sessions over a period of 4 to 6 weeks, with follow-up immediately, 6-months, and 12-months following the intervention.
Results: Of the 34 individuals who enrolled in the study, 10 out of 14 participants in the NMES group completed the study, while 14 out of 15 participants in the TENS group completed the study. Patient-reported outcome measures improved across both groups at the 12-month follow-up. The NMES group showed improvements beyond the TENS group at 6 and 12 months for the IdFAI and FAAM-Sport measures. Large, but non-significant effects were observed in dynamic balance measures following the intervention.
Rolling the field forward: The researchers in this study explored how augmenting rehabilitation with treatments designed to be neuromodulatory (i.e. improve muscle reflexive actions) may improve clinician- and patient-oriented measures of function. The results showed improved long-term improvements in perceived disease-oriented function in individuals that received exercise and NMES, compared to those receiving exercise and TENS, with these improvements being in disease-oriented outcomes (IdFAI) and those reflecting more challenging function (FAAM-Sport). Importantly, these outcomes were achieved with a program carried out at home.
Question for the researchers: Do the authors feel that balance exercises were the ideal therapeutic exercise to pair with the NMES and TENS interventions? Given the programming needed on the stimulators, what steps would be needed to make this treatment more accessible to the average practicing clinician?